Safe CNC machining-center operation depends on disciplined setup, machining, cleaning, and shutdown practices. This article provides a detailed safety checklist for trained operators, covering personal protective equipment, lubrication and guard inspections, correct clamping, tool changes, first-part checks, dry runs, rapid feed, chip removal, alarms, emergency response, chemical cleaning, maintenance lockout, and end-of-shift housekeeping. It also explains how clear drawings, verified offsets, proper cutting limits, and accurate records help prevent tool collisions, workpiece release, machine damage, and serious preventable shop-floor injuries.